Industrial Medicinal Chemistry

Description: 
1. Vassilis Demopoulos: Retrosynthetic methods: a) disconactions based on one functional group, b) disconactions based on two functional groups, c) disconactions of amines, d) pericyclic disconactions, and e) disconactions of heterocyclic rings. 2. Dimitra Hadjipavlou-Litina: Methods for the synthesis of ΜΜΡs inhibitors- the example of marimastat. Methods for the synthesis of coumarin anticoagulant and coumarin derivatives with biological activity. Methods for the synthesis of phospholipase inhibitors. Combinatorial chemistry – phase transfer catalysis. 3. Ioannis Nicolaou: Designing of compounds of pharmaceutical interest avoiding toxicity, like: a) hepatotoxicity, b) cardiovascular toxicity, c) genotoxicity – mutagenesis, d) phospholipidosis, e) phototoxicity, and f) idiosyncratic toxicity.
ECTS: 
10.00
Teaching Hours: 
6
Semester: 
2