Aristotle University of ThessalonikiΠεριγραφή:
1. Vassilis Demopoulos:
Retrosynthetic methods: a) disconactions based on one functional group, b) disconactions based on two functional groups, c) disconactions of amines, d) pericyclic disconactions, and e) disconactions of heterocyclic rings.
2. Dimitra Hadjipavlou-Litina:
Methods for the synthesis of ΜΜΡs inhibitors- the example of marimastat.
Methods for the synthesis of coumarin anticoagulant and coumarin derivatives with biological activity.
Methods for the synthesis of phospholipase inhibitors.
Combinatorial chemistry – phase transfer catalysis.
3. Ioannis Nicolaou:
Designing of compounds of pharmaceutical interest avoiding toxicity, like: a) hepatotoxicity, b) cardiovascular toxicity, c) genotoxicity – mutagenesis, d) phospholipidosis, e) phototoxicity, and f) idiosyncratic toxicity.
ECTS: 10
Ώρες Διδασκαλίας: 6
Εξάμηνο: 2
Description:
1. Vassilis Demopoulos:
Retrosynthetic methods: a) disconactions based on one functional group, b) disconactions based on two functional groups, c) disconactions of amines, d) pericyclic disconactions, and e) disconactions of heterocyclic rings.
2. Dimitra Hadjipavlou-Litina:
Methods for the synthesis of ΜΜΡs inhibitors- the example of marimastat.
Methods for the synthesis of coumarin anticoagulant and coumarin derivatives with biological activity.
Methods for the synthesis of phospholipase inhibitors.
Combinatorial chemistry – phase transfer catalysis.
3. Ioannis Nicolaou:
Designing of compounds of pharmaceutical interest avoiding toxicity, like: a) hepatotoxicity, b) cardiovascular toxicity, c) genotoxicity – mutagenesis, d) phospholipidosis, e) phototoxicity, and f) idiosyncratic toxicity.
ECTS: 10
Hours: 6
Semester: 2